ANAPC4 anticorps (N-Term)

N° du produit ABIN499297

Cet anticorps Lapin Polyclonal détecte spécifiquement ANAPC4 dans WB et EIA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ANAPC4 anticorps (N-Term) (ABIN499297)

Antigène: ANAPC4 (Anaphase Promoting Complex Subunit 4 (ANAPC4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ANAPC4 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-ANAPC4 anticorps

Épitope: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogène: APC4 antibody was raised against a 14 amino acid peptide near the amino terminus of human APC4.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: APC4 antibody can be used for detection of APC4 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur ANAPC4

Antigène: ANAPC4 (Anaphase Promoting Complex Subunit 4 (ANAPC4))

Autre désignation: APC4 / ANAPC4

Sujet: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC4 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC4, it is thought that APC4 associates with other APC/C components APC1, APC5, and CDC23 interdependently, such that loss of any one subunit reduces binding between the remaining three.Synonyms: Anaphase-promoting complex subunit 4, Cyclosome subunit 4

ID gène: 29945

UniProt: Q9UJX5

Pathways: M Phase