ASAH2 anticorps (C-Term)

N° du produit ABIN499341

Détail du produit anti-ASAH2 anticorps

Antigène: ASAH2 (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASAH2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to ASAH2.

Purification: Affinity chromatography purified via peptide column

Immunogène: ASAH2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human ASAH2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: ASAH2 antibody can be used for detection of ASAH2 at 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur ASAH2

Antigène: ASAH2 (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2))

Autre désignation: Neutral Ceramidase / ASAH2 (ASAH2 Produits)

Synonymes: anticorps BCDase, anticorps HNAC1, anticorps LCDase, anticorps N-CDase, anticorps NCDase, anticorps AI585898, anticorps N-acylsphingosine amidohydrolase 2, anticorps ASAH2, anticorps Asah2

Sujet: Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.Synonyms: Acylsphingosine deacylase 2, BCDase, HNAC1, LCDase, N-acylsphingosine amidohydrolase 2, Non-lysosomal ceramidase, hCD

ID gène: 56624

NCBI Accession: NP_063946

UniProt: Q9NR71