BCAS2 anticorps (C-Term)

N° du produit ABIN499423

Cet anticorps Lapin Polyclonal détecte spécifiquement BCAS2 dans WB et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour BCAS2 anticorps (C-Term) (ABIN499423)

Antigène: BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCAS2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-BCAS2 anticorps

Épitope: C-Term

Purification: Affinity chromatography purified via peptide column

Immunogène: BCAS2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human BCAS2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: BCAS2 antibody can be used for detection of BCAS2 at 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur BCAS2

Antigène: BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))

Autre désignation: BCAS2 / DAM1

Sujet: BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53-null or -mutant cells, this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer.Synonyms: Breast carcinoma-amplified sequence 2, DNA amplified in mammary carcinoma 1 protein, Pre-mRNA-splicing factor SPF27, SPF27

ID gène: 10286

UniProt: O75934