BCL2L13 anticorps (Intermediate Domain)

N° du produit ABIN499433

L’anticorps anti-BCL2L13 Polyclonal Lapin est utilisé pour la détection de BCL2L13 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC (p) et EIA.

Aperçu rapide pour BCL2L13 anticorps (Intermediate Domain) (ABIN499433)

Antigène: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCL2L13 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-BCL2L13 anticorps

Épitope: Intermediate Domain

Specificité: Bcl-rambo antibody was raised against a 15 amino acid peptide from near the center of human Bcl-rambo.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human Bcl-rambo / Bcl-2 like protein 13 / Mil1 (Intermediate Domain) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Bcl-rambo antibody can be used for the detection of Bcl-rambo at 2 μg/mL. K562 cell lysate can be used as positive control. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BCL2L13

Antigène: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 (4). Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways (4).Synonyms: BCL2L13, Bcl-2-like protein 13, Bcl-rambo, Bcl2-L-13, CD003, MIL1

ID gène: 23786

UniProt: Q9BXK5

Pathways: Positive Regulation of Endopeptidase Activity