BCL2A1 anticorps (N-Term)

N° du produit ABIN499453

Détail du produit anti-BCL2A1 anticorps

Antigène: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCL2A1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to BFL-1.

Purification: Affinity chromatography purified via peptide column

Immunogène: Bfl-1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human Bfl-1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Bfl-1 antibody can be used for the detection of Bfl-1 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BCL2A1

Antigène: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Abstract: BCL2A1 Produits

Synonymes: anticorps ACC-1, anticorps ACC-2, anticorps BCL2L5, anticorps BFL1, anticorps GRS, anticorps HBPA1, anticorps Bcl2a1d, anticorps BCL2A1, anticorps BCL2 related protein A1, anticorps BCL2-related protein A1, anticorps BCL2A1, anticorps Bcl2a1

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist. Presumably due to post-translational modifications, Bfl-1 is often observed at higher molecular weight in SDS-PAGE than its predicted molecular weight would suggest.Synonyms: BCL2A1, BCL2L5, BFL1, Bcl-2-like protein 5, Bcl-2-related protein A1, GRS, HBPA1, Hemopoietic-specific early response protein, Protein BFL-1

ID gène: 597

NCBI Accession: NP_004040

UniProt: Q16548