BCL2A1 anticorps (N-Term)

N° du produit ABIN499453

Cet anticorps Lapin Polyclonal détecte spécifiquement BCL2A1 dans WB et EIA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BCL2A1 anticorps (N-Term) (ABIN499453)

Antigène: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCL2A1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-BCL2A1 anticorps

Épitope: N-Term

Specificité: This antibody reacts to BFL-1.

Purification: Affinity chromatography purified via peptide column

Immunogène: Bfl-1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human Bfl-1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Bfl-1 antibody can be used for the detection of Bfl-1 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BCL2A1

Antigène: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist. Presumably due to post-translational modifications, Bfl-1 is often observed at higher molecular weight in SDS-PAGE than its predicted molecular weight would suggest.Synonyms: BCL2A1, BCL2L5, BFL1, Bcl-2-like protein 5, Bcl-2-related protein A1, GRS, HBPA1, Hemopoietic-specific early response protein, Protein BFL-1

ID gène: 597

NCBI Accession: NP_004040

UniProt: Q16548