BICD2 anticorps (C-Term)

N° du produit ABIN499457

L’anticorps anti-BICD2 Polyclonal Lapin est utilisé pour la détection de BICD2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et EIA.

Aperçu rapide pour BICD2 anticorps (C-Term) (ABIN499457)

Antigène: BICD2 (Bicaudal D Homolog 2 (BICD2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BICD2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-BICD2 anticorps

Épitope: C-Term

Specificité: This antibody reacts to BICD2. It will not cross-react with BICD1.

Purification: Affinity chromatography purified via peptide column

Immunogène: BICD2 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human BICD2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: BICD2 antibody can be used for detection of BICD2 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BICD2

Antigène: BICD2 (Bicaudal D Homolog 2 (BICD2))

Autre désignation: BICD2

Sujet: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.Synonyms: Bic-D2, KIAA0699, Protein bicaudal D homolog 2

ID gène: 23299

UniProt: Q8TD16

Pathways: Maintenance of Protein Location