SH3GLB1 anticorps (C-Term)

N° du produit ABIN499465

Cet anticorps Lapin Polyclonal détecte spécifiquement SH3GLB1 dans WB, IF et EIA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour SH3GLB1 anticorps (C-Term) (ABIN499465)

Antigène: SH3GLB1 (SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH3GLB1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-SH3GLB1 anticorps

Épitope: C-Term

Specificité: This anitbody reacts to BIF.

Purification: Affinity chromatography purified via peptide column

Immunogène: BIF antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human BIF.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western BLot: BIF antibody can be used for the detection of BIF at 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur SH3GLB1

Antigène: SH3GLB1 (SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1))

Autre désignation: Endophilin-B1

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family such as Bax appear to control the activation of these enzymes. Bax activity was found to be regulated by its association with Bax-interacting factor 1 (BIF), a member of the endophilin B family that is associated with intracellular membranes.. Following this interaction, Bax undergoes a conformational change and translocates to mitochondrial membranes. The Bax/BIF interaction appears to be enhanced by apoptotic stimuli, suggesting that BIF acts as the trigger to activate Bax, and as suppression of BIF promoted HeLa cell colony formation in soft agar, it may have a role in the suppression of cancer progression. At least two isoforms of BIF are known to exist.Synonyms: BIF1, Bax-interacting factor 1, Bif-1, KIAA0491, SH3 domain-containing GRB2-like protein B1, SH3GLB1

ID gène: 51100

UniProt: Q9Y371

Pathways: Autophagy