BMF anticorps (N-Term)

N° du produit ABIN499481

L’anticorps Lapin Polyclonal anti-BMF a été validé pour WB, EIA et IF. Il convient pour détecter BMF dans des échantillons de Humain et Souris.

Aperçu rapide pour BMF anticorps (N-Term) (ABIN499481)

Antigène: BMF (Bcl2 Modifying Factor (BMF))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMF est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Détail du produit anti-BMF anticorps

Épitope: N-Term

Specificité: EndoG antibody was raised with a synthetic peptide corresponding to 15 amino acids near the amino terminus of human EndoG.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human Bmf (N-Terminus) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Bmf antibody can be used for detection of Bmf at 2 μg/mL. HepG2 or 293 celllysate can be used as a positive control and a band at approximately 25 kDa can bedetected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BMF

Antigène: BMF (Bcl2 Modifying Factor (BMF))

Autre désignation: BMF

Sujet: Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor) (1). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program (1,2). Bmf is constitutively expressed in many tissues (1,2).Synonyms: Bcl-2-modifying factor

ID gène: 90427

NCBI Accession: NP_277038

UniProt: Q96LC9