BORA anticorps (C-Term)

N° du produit ABIN499489

Cet anticorps Lapin Polyclonal détecte spécifiquement BORA dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour BORA anticorps (C-Term) (ABIN499489)

Antigène: BORA (Protein Aurora Borealis (BORA))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BORA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-BORA anticorps

Épitope: C-Term

Specificité: This antibody reacts to Bora.

Purification: Affinity chromatography purified via peptide column

Immunogène: Bora antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human Bora.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Bora antibody can be used for detection of Bora at 1-2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BORA

Antigène: BORA (Protein Aurora Borealis (BORA))

Autre désignation: Protein Aurora Borealis

Sujet: Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.Synonyms: BORA, C13orf34, FLJ22624, HsBora

ID gène: 79866

UniProt: Q6PGQ7