BRCC3 anticorps (N-Term)

N° du produit ABIN499495

Détail du produit anti-BRCC3 anticorps

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCC3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This anitbody reacts to BRCC36.

Purification: Affinity chromatography purified via peptide column

Immunogène: BRCC36 antibody was raised against a 18 amino acid peptide from near the amino terminus of human BRCC36.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western BLot: BRCC36 antibody can be used for detection of BRCC36 at 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BRCC3

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Autre désignation: BRCC3 (BRCC3 Produits)

Synonymes: anticorps CXorf53, anticorps BRCC3, anticorps xtp1, anticorps brcc3, anticorps BRCC36, anticorps brcc36, anticorps C6.1A, anticorps BRCA1/BRCA2-containing complex subunit 3, anticorps DEP domain containing 1B, anticorps BRCA1/BRCA2-containing complex, subunit 3, anticorps BRCA1/BRCA2-containing complex subunit 3 L homeolog, anticorps BRCC3, anticorps depdc1b, anticorps brcc3, anticorps Brcc3, anticorps brcc3.L

Sujet: Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of BRCC36 are known to exist.Synonyms: BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRCC36, BRISC complex subunit BRCC36, C6.1A, CXorf53, Lys-63-specific deubiquitinase BRCC36

ID gène: 79184

NCBI Accession: NP_077308

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus