BST2 anticorps (N-Term)

N° du produit ABIN499505

L’anticorps Lapin Polyclonal anti-BST2 a été validé pour WB et EIA. Il convient pour détecter BST2 dans des échantillons de Humain et Souris.

Aperçu rapide pour BST2 anticorps (N-Term) (ABIN499505)

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BST2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-BST2 anticorps

Épitope: N-Term

Specificité: This antibody reacts to Bst2.

Purification: Affinity chromatography purified via peptide column

Immunogène: Bst2 antibody was raised against a 18 amino acid peptide near the amino terminus of the mouse Bst2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Bst2 antibody can be used for detection of Bst2 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BST2

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Autre désignation: CD317 / BST2

Sujet: Bst2 was first identified as a novel terminal B-cell-restricted antigen termed HM1.24 that is expressed on certain bone marrow cells as well as other tissues. The surface expression of Bst2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line, suggesting that this protein is involved in pre-B-cell growth. Later experiments also showed it to be upregulated in several myeloma cells. More recently, Bst2 was identified an inhibitor of retroviral release from human cells whose activity is antagonized by the HIV-1 accessory protein Vpu. While Bst2 caused retention of virions on cell surfaces or endocytosis into Bst2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release. This activity may represent a potential therapeutic strategy for the treatment of HIV/AIDS.Synonyms: BST-2, Bone marrow stromal antigen 2, HM1.24 antigen, Tetherin

ID gène: 69550

UniProt: Q8R2Q8

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response