BUB1 anticorps (N-Term)

N° du produit ABIN499509

Cet anticorps anti-BUB1 Polyclonal Lapin (ABIN499509) détecte spécifiquement BUB1 dans WB, IF et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour BUB1 anticorps (N-Term) (ABIN499509)

Antigène: BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BUB1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-BUB1 anticorps

Épitope: N-Term

Specificité: This antibody reacts to Bub1.

Purification: Affinity chromatography purified via peptide column

Immunogène: Bub1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human Bub1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Bub1 antibody can be used for detection of bub1 at 2 - 4 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BUB1

Antigène: BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))

Autre désignation: BUB1A

Sujet: Bub1 was initially identified as the mammalian homolog to the yeast protein through a cDNA screen. Bub1 encodes a kinase involved in the formation of the spindle checkpoint, an important mechanism that ensures high fidelity mitotic chromosome segregation. It is thought to be required for assembly of a functional inner centromere, sister chromatid cohesion via targeting of the Shugoshim protein and metaphase congression. Bub1 functions by phosphorylating cdc20, a member of the mitotic checkpoint complex and activating the spindle checkpoint. A related protein kinase Bub3 interacts with Bub1 and targets it to kinetochores prior to chromosome alignment. Mutations in bub1 have been associated with aneuploidy and several forms of cancer.Synonyms: BUB1L, Mitotic checkpoint serine/threonine-protein kinase BUB1

ID gène: 699

UniProt: O43683