PLEKHO1 anticorps (C-Term)

N° du produit ABIN499637

L’anticorps anti-PLEKHO1 Polyclonal Lapin est utilisé pour la détection de PLEKHO1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et EIA.

Aperçu rapide pour PLEKHO1 anticorps (C-Term) (ABIN499637)

Antigène: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLEKHO1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-PLEKHO1 anticorps

Épitope: C-Term

Purification: Affinity chromatography purified via peptide column

Immunogène: CKIP1 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human CKIP1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: CKIP1 antibody can be used for detection of CKIP1 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur PLEKHO1

Antigène: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Autre désignation: PLEKHO1 / CKIP1

Sujet: CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.Synonyms: C-Jun-binding protein, CK2-interacting protein 1, CKIP-1, Casein kinase 2-interacting protein 1, HQ0024c, JBP, OC120, Osteoclast maturation-associated gene 120 protein, PH domain-containing family O member 1, Pleckstrin homology domain-containing family O member 1

ID gène: 51177

NCBI Accession: NP_057358

UniProt: Q53GL0