DAD1 anticorps

N° du produit ABIN499706

L’anticorps Lapin Polyclonal anti-DAD1 a été validé pour WB, IF et EIA. Il convient pour détecter DAD1 dans des échantillons de Humain et Souris.

Aperçu rapide pour DAD1 anticorps (ABIN499706)

Antigène: DAD1 (Defender Against Cell Death 1 (DAD1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DAD1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-DAD1 anticorps

Specificité: DAD1 antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human DAD1.

Purification: Ion exchange chromatography

Immunogène: Murine DAD1 Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 0.5 to 2 μg/mL. Despite its predicted molecular weight, DAD1 migrates at approx. 22 kDa in SDS-PAGE. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur DAD1

Antigène: DAD1 (Defender Against Cell Death 1 (DAD1))

Autre désignation: DAD1

Sujet: Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death (1), a process important for normal organism development and tissue homeostasis (2). DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity (3,4). Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death (5,6). Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas (7), indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.Synonyms: DAD-1, OST2, defender against cell death 1, dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1, oligosaccharyl transferase subunit DAD1

ID gène: 1603

UniProt: P61803