DNAL1 anticorps (C-Term)

N° du produit ABIN499752

Détail du produit anti-DNAL1 anticorps

Antigène: DNAL1 (Dynein, Axonemal, Light Chain 1 (DNAL1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNAL1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts top DNAL1.

Purification: Affinity chromatography purified via peptide column

Immunogène: DNAL1 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human DNAL1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur DNAL1

Antigène: DNAL1 (Dynein, Axonemal, Light Chain 1 (DNAL1))

Autre désignation: DNAL1 (DNAL1 Produits)

Synonymes: anticorps C14orf168, anticorps CILD16, anticorps 1700010H15Rik, anticorps AW121714, anticorps Dnalc1, anticorps E330027P08Rik, anticorps wu:fc89a04, anticorps zgc:92542, anticorps dynein axonemal light chain 1, anticorps dynein, axonemal, light chain 1 L homeolog, anticorps dynein, axonemal, light chain 1, anticorps DNAL1, anticorps dnal1.L, anticorps Dnal1, anticorps dnal1

Sujet: DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.Synonyms: C14orf168, Dynein light chain 1 axonemal

ID gène: 83544

NCBI Accession: NP_113615

UniProt: Q4LDG9