FRMPD1 anticorps (C-Term)

N° du produit ABIN499857

Cet anticorps anti-FRMPD1 Polyclonal Lapin (ABIN499857) détecte spécifiquement FRMPD1 dans WB, IF et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour FRMPD1 anticorps (C-Term) (ABIN499857)

Antigène: FRMPD1 (FERM and PDZ Domain Containing 1 (FRMPD1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FRMPD1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-FRMPD1 anticorps

Épitope: C-Term

Purification: Affinity chromatography purified via peptide column

Immunogène: FRMPD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human FRMPD1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur FRMPD1

Antigène: FRMPD1 (FERM and PDZ Domain Containing 1 (FRMPD1))

Autre désignation: FRMPD1

Sujet: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50 % and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.Synonyms: FERM and PDZ domain-containing protein 1, FERM domain-containing protein 2, FRMD2, KIAA0967

ID gène: 22844

NCBI Accession: NP_055722

UniProt: Q5SYB0