IKAP/p150 anticorps (C-Term)

N° du produit ABIN499964

L’anticorps Lapin Polyclonal anti-IKAP/p150 a été validé pour WB, IF et EIA. Il convient pour détecter IKAP/p150 dans des échantillons de Humain et Souris.

Aperçu rapide pour IKAP/p150 anticorps (C-Term) (ABIN499964)

Antigène: IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKAP/p150 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-IKAP/p150 anticorps

Épitope: C-Term

Specificité: This antibody reacts to IKAP.

Purification: Affinity chromatography purified via peptide column

Immunogène: IKAP antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IKAP.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 0.5 to 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur IKAP/p150

Antigène: IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

Autre désignation: ELP1 / IKBKAP

Sujet: IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKalpha, IKKbeta, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.Synonyms: Elongator complex protein 1, IKAP, IKK complex-associated protein, IkappaB kinase complex-associated protein, p150

ID gène: 8518

UniProt: O95163