IRF8 anticorps

N° du produit ABIN500062

Détail du produit anti-IRF8 anticorps

Antigène: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRF8 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human IRF8 Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur IRF8

Antigène: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Autre désignation: IRF8 / ICSBP1 (IRF8 Produits)

Synonymes: anticorps zgc:92252, anticorps IRF8, anticorps MGC140338, anticorps DKFZp469B0320, anticorps H-ICSBP, anticorps ICSBP, anticorps ICSBP1, anticorps IRF-8, anticorps icsbp1, anticorps AI893568, anticorps Icsbp1, anticorps Myls, anticorps interferon regulatory factor 8, anticorps interferon regulatory factor 8 L homeolog, anticorps irf8, anticorps IRF8, anticorps irf8.L, anticorps Irf8

Sujet: Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases (2,3), but IRF8 mediates activation of NF-kappaB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells (4,5). Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia (6).Synonyms: IRF-8, Interferon consensus sequence-binding protein, Interferon regulatory factor 8

ID gène: 3394

NCBI Accession: NP_002154

UniProt: Q02556

Pathways: Cellular Response to Molecule of Bacterial Origin