IRGC anticorps (C-Term)

N° du produit ABIN500066

L’anticorps Lapin Polyclonal anti-IRGC a été validé pour WB, IF et EIA. Il convient pour détecter IRGC dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour IRGC anticorps (C-Term) (ABIN500066)

Antigène: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRGC est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-IRGC anticorps

Épitope: C-Term

Specificité: This antibody detects IRGC at C-term. It will recognize both isoforms.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: IRGC antibody was raised against a 12 amino acid peptide near the carboxy terminus of human IRGC.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur IRGC

Antigène: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Autre désignation: IRGC

Sujet: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans. Two isoforms of IRGC are known to exist.Synonyms: Cinema 1, IIGP5, IRGC1, Immunity-related GTPase cinema 1, Interferon-inducible GTPase 5

ID gène: 56269

NCBI Accession: NP_062558

UniProt: Q6NXR0