Junctophilin 1 anticorps (C-Term)

N° du produit ABIN500094

Détail du produit anti-Junctophilin 1 anticorps

Antigène: Junctophilin 1 (JPH1)

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Junctophilin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects JPH1.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: JPH1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human JPH1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur Junctophilin 1

Antigène: Junctophilin 1 (JPH1)

Abstract: JPH1 Produits

Synonymes: anticorps JP-1, anticorps JP1, anticorps ENSMUSG00000054314, anticorps Jp1, anticorps bZ1M12.3, anticorps jph1, anticorps si:rp71-1m12.3, anticorps Jph1, anticorps junctophilin 1, anticorps junctophilin 1a, anticorps junctophilin-1, anticorps JPH1, anticorps Jph1, anticorps jph1, anticorps jph1a, anticorps LOC100547979

Sujet: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH1 is essential for stabilizing the T-tubule and SR membranes to form junctions and provide an environment for the assembly of receptors such as the ryanodine receptor type 1 (RyR1).Synonyms: JP1

ID gène: 56704

NCBI Accession: NP_065698

UniProt: Q9HDC5