DNMT3A anticorps (AA 26-100) (AbBy Fluor® 750)

N° du produit ABIN5001415

L’anticorps Lapin Polyclonal anti-DNMT3A a été validé pour FACS, IF (cc) et IF (p). Il convient pour détecter DNMT3A dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DNMT3A anticorps (AA 26-100) (AbBy Fluor® 750) (ABIN5001415)

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNMT3A est conjugé à/à la AbBy Fluor® 750

Application: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-DNMT3A anticorps (AbBy Fluor® 750)

Épitope: AA 26-100

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Dnmt3a

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur DNMT3A

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Autre désignation: Dnmt3a

Sujet:

Synonyms: TBRS, DNMT3A2, M.HsaIIIA, DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA

Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

ID gène: 1788

UniProt: Q9Y6K1