MADD anticorps (C-Term)

N° du produit ABIN500216

Détail du produit anti-MADD anticorps

Antigène: MADD (MAP-Kinase Activating Death Domain (MADD))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MADD est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody detects MADD at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: DEAE purified

Immunogène: MADD antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human MADD.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1: 250 - 1: 500 dilution, 200 to 220 kDa bands should be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur MADD

Antigène: MADD (MAP-Kinase Activating Death Domain (MADD))

Autre désignation: MADD (MADD Produits)

Synonymes: anticorps MADD, anticorps MGC145371, anticorps DENN, anticorps IG20, anticorps RAB3GEP, anticorps 9630059K23Rik, anticorps MAP kinase activating death domain, anticorps MAP-kinase activating death domain, anticorps MADD, anticorps madd, anticorps Madd

Sujet: MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains. Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2. MADD shares 98 % identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94 % overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87 % identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNFR1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.Synonyms: DENN, IG20, MAP kinase-activating death domain protein, RAB3GEP, Rab3 GDP/GTP exchange factor

ID gène: 8567

UniProt: Q8WXG6

Pathways: Caspase Cascade in Apoptosis