MOAP1 anticorps (Center)

N° du produit ABIN500228

L’anticorps Lapin Polyclonal anti-MOAP1 a été validé pour WB et EIA. Il convient pour détecter MOAP1 dans des échantillons de Humain et Souris.

Aperçu rapide pour MOAP1 anticorps (Center) (ABIN500228)

Antigène: MOAP1 (Modulator of Apoptosis 1 (MOAP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MOAP1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-MOAP1 anticorps

Épitope: Center

Specificité: This antibody detects Modulator of apoptosis 1 at enter.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogène: MAP-1 antibody was raised against a 15 amino acid peptide from near the center of human MAP-1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur MOAP1

Antigène: MOAP1 (Modulator of Apoptosis 1 (MOAP1))

Autre désignation: MOAP1

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo (4). It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis (5).Synonyms: MAP-1, MAP1, Modulator of apoptosis 1

ID gène: 64112

NCBI Accession: NP_071434

UniProt: Q96BY2

Pathways: Positive Regulation of Endopeptidase Activity