Norrie Disease (Pseudoglioma) anticorps (N-Term)

N° du produit ABIN500373

Détail du produit anti-Norrie Disease (Pseudoglioma) anticorps

Antigène: Norrie Disease (Pseudoglioma) (NDP)

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Norrie Disease (Pseudoglioma) est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody detects NDP.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogène: Norrin antibody was raised against an 18 amino acid peptide from near the amino terminus of human Norrin.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur Norrie Disease (Pseudoglioma)

Antigène: Norrie Disease (Pseudoglioma) (NDP)

Autre désignation: NDP (NDP Produits)

Synonymes: anticorps EVR2, anticorps FEVR, anticorps ND, anticorps evr2, anticorps fevr, anticorps xnorrin, anticorps Ndph, anticorps RGD1563968, anticorps NDP, norrin cystine knot growth factor, anticorps Norrie disease (pseudoglioma) L homeolog, anticorps Norrie disease (pseudoglioma) (human), anticorps NDP, anticorps ndp.L, anticorps Ndp

Sujet: Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/b-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina, transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/b-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.Synonyms: EVR2, Norrie disease protein, Norrin

ID gène: 4693

NCBI Accession: NP_000257

UniProt: Q00604

Pathways: Sensory Perception of Sound