TP53INP1 anticorps (N-Term)

N° du produit ABIN500435

L’anticorps Lapin Polyclonal anti-TP53INP1 a été validé pour WB, IHC (p) et EIA. Il convient pour détecter TP53INP1 dans des échantillons de Humain, Souris et Rat. Il y a 1 publication disponible.

Aperçu rapide pour TP53INP1 anticorps (N-Term) (ABIN500435)

Antigène: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TP53INP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-TP53INP1 anticorps

Épitope: N-Term

Specificité: This antibody detects TP53INP1.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Peptide Affinity Chromatography

Immunogène: A synthetic peptide corresponding to 14 amino acids near the amino terminus of Human p53DINP1. .Remarks: This sequence is identical between apha and beta forms of the p53DINP1 proteins, and differs by one amino acid from those of Mouse.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot (1-2 μg/mL). Human lung tissue lysate can be used as a Positive Control and a band at 27 kDa can bedetected. A lower band at 18 kDa was detected in Human spleen, and Mouse liver andkidney tissue lysates, which may represent the p53DINP1-beta form. Immunohistochemistry on Paraffin Sections (2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Références pour anticorps anti-TP53INP1 (ABIN500435)

Ferrajoli, Ivan, Ciccone, Shimizu, Kita, Ohtsuka, DAbundo, Qiang, Lerner, Nouraee, Rabe, Rassenti, Van Roosbroeck, Manning, Yuan, Zhang, Shanafelt, Wierda, Sabbioni, Tarrand, Estrov, Radovich, Liang et al.: "Epstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival. ..." dans: EBioMedicine, Vol. 2, Issue 6, pp. 572-82, (2016) (PubMed).

Détails sur TP53INP1

Antigène: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Autre désignation: TP53INP1

Sujet: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein 1) and SIP (for stress induced protein) in human and mouse (1,2).?A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks (1). p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-a and p53DINP1-b or SIP27 and SIP18 (1,2). p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress (2).Synonyms: P53DINP1, SIP, Stress-induced protein, Tumor protein p53-inducible nuclear protein 1, p53-dependent damage-inducible nuclear protein 1, p53-inducible nuclear protein 1

ID gène: 94241

UniProt: Q96A56