CUL9 anticorps (C-Term)

N° du produit ABIN500449

Cet anticorps Lapin Polyclonal détecte spécifiquement CUL9 dans WB, IF et EIA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour CUL9 anticorps (C-Term) (ABIN500449)

Antigène: CUL9 (Cullin 9 (CUL9))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CUL9 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-CUL9 anticorps

Épitope: C-Term

Specificité: This antibody detects Cullin-9.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogène: PARC antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human PARC.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot. Immuncytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur CUL9

Antigène: CUL9 (Cullin 9 (CUL9))

Autre désignation: Cullin-9

Sujet: The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.Synonyms: CUL-9, H7AP1, KIAA0708, PARC, UbcH7-associated protein 1, p53-associated parkin-like cytoplasmic protein

ID gène: 23113

NCBI Accession: NP_055904

UniProt: Q8IWT3