PDCD5 anticorps (C-Term)

N° du produit ABIN500463

Cet anticorps anti-PDCD5 est un anticorps Lapin Polyclonal détectant PDCD5 dans WB, IF et EIA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour PDCD5 anticorps (C-Term) (ABIN500463)

Antigène: PDCD5 (Programmed Cell Death 5 (PDCD5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDCD5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-PDCD5 anticorps

Épitope: C-Term

Specificité: This antibody detects PDCD5 at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: PDCD5 antibody was raised against a 21 amino acid peptide from near the carboxy terminus of human PDCD5.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur PDCD5

Antigène: PDCD5 (Programmed Cell Death 5 (PDCD5))

Autre désignation: PDCD5

Sujet: Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5?-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.Synonyms: Programmed cell death protein 5, TF-1 cell apoptosis-related protein 19, TFAR19

ID gène: 9141

NCBI Accession: NP_004699

UniProt: O14737