FBXL20 anticorps (C-Term)

N° du produit ABIN500690

L’anticorps Lapin Polyclonal anti-FBXL20 a été validé pour WB, IHC (p) et EIA. Il convient pour détecter FBXL20 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour FBXL20 anticorps (C-Term) (ABIN500690)

Antigène: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXL20 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-FBXL20 anticorps

Épitope: C-Term

Specificité: This antibody detects FBXL20 at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: FBXL20 antibody was raised against a 18 amino acid peptide near the carboxy terminus of the human FBXL20.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur FBXL20

Antigène: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Autre désignation: FBXL20

Sujet: Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.Synonyms: F-box and leucine-rich repeat protein 20, F-box/LRR-repeat protein 2-like, F-box/LRR-repeat protein 20, FBL2

ID gène: 84961

NCBI Accession: NP_116264

UniProt: Q96IG2