SHoc2/Sur8 anticorps (N-Term)

N° du produit ABIN500706

Cet anticorps anti-SHoc2/Sur8 Polyclonal Lapin (ABIN500706) détecte spécifiquement SHoc2/Sur8 dans WB, IHC (p) et EIA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SHoc2/Sur8 anticorps (N-Term) (ABIN500706)

Antigène: SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHoc2/Sur8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-SHoc2/Sur8 anticorps

Épitope: N-Term

Specificité: This antibody detects SHOC2.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: SHOC2 antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur SHoc2/Sur8

Antigène: SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))

Autre désignation: SHOC2

Sujet: SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.Synonyms: KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SHOC-2, SOC2, SUR8

ID gène: 8036

NCBI Accession: NP_031399

UniProt: Q9UQ13