SIRT2 anticorps (N-Term)

N° du produit ABIN500726

L’anticorps Lapin Polyclonal anti-SIRT2 a été validé pour WB, IHC (p) et EIA. Il convient pour détecter SIRT2 dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour SIRT2 anticorps (N-Term) (ABIN500726)

Antigène: SIRT2 (Sirtuin 2 (SIRT2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-SIRT2 anticorps

Épitope: N-Term

Specificité: This antibody detects SIRT2 / SIR2 at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromtography

Immunogène: SIRT2 antibody was raised against a 17 amino acid peptide near the amino terminus of the human SIRT2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 2.5 - 5 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur SIRT2

Antigène: SIRT2 (Sirtuin 2 (SIRT2))

Autre désignation: SIRT2 / SIR2

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG16, another member of the autophagy protein family, forms a complex with the ATG5-ATG12 conjugate. This multimeric protein has been shown to be essential for autophagosome formation in both yeast and mammals and targets the ATG5-ATG12 complex to the autophagic isolation membrane during the formation of the autophagosome. Because mammalian ATG16 has seven WD-repeats in its C-terminal domain, it has been suggested that these may form a platform for further protein-protein interactions. Multiple isoforms of ATG16 are known to exist.Synonyms: NAD-dependent deacetylase sirtuin-2, SIR2-like protein 2, SIR2L, SIR2L2, SIRT-2, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae), sirtuin 2, sirtuin type 2, sirtuin-2

ID gène: 22933

NCBI Accession: NP_036369

UniProt: Q8IXJ6