STEAP1 anticorps (C-Term)

N° du produit ABIN500817

Cet anticorps anti-STEAP1 Polyclonal Lapin (ABIN500817) détecte spécifiquement STEAP1 dans WB, IHC (p) et EIA. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour STEAP1 anticorps (C-Term) (ABIN500817)

Antigène: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STEAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-STEAP1 anticorps

Épitope: C-Term

Specificité: This antibody detects STEAP1 at C-term. It does not cross-react with other STEAP proteins.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: STEAP1 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human STEAP1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur STEAP1

Antigène: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Autre désignation: STEAP / STEAP1

Sujet: The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain, unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.Synonyms: Metalloreductase STEAP1, PRSS24, STEAP-1, Six-transmembrane epithelial antigen of prostate 1

ID gène: 26872

NCBI Accession: NP_036581

Pathways: Transition Metal Ion Homeostasis