SESN1 anticorps (AA 401-492) (AbBy Fluor® 680)

N° du produit ABIN5008245

Cet anticorps Lapin Polyclonal détecte spécifiquement SESN1 dans WB, FACS, IF (cc) et IF (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour SESN1 anticorps (AA 401-492) (AbBy Fluor® 680) (ABIN5008245)

Antigène: SESN1 (Sestrin 1 (SESN1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SESN1 est conjugé à/à la AbBy Fluor® 680

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-SESN1 anticorps (AbBy Fluor® 680)

Épitope: AA 401-492

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SESN1/PA26

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur SESN1

Antigène: SESN1 (Sestrin 1 (SESN1))

Autre désignation: PA26

Sujet:

Synonyms: p53 regulated PA26 nuclear protein, p53 regulated protein PA26, p53-regulated protein PA26, PA26, sesn1, SESN1_HUMAN, SEST1, sestrin 1, Sestrin-1.

Background: Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and the mitotic inhibitory protein p21. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase, and it apparently acts in concert with GADD 153 in inducing growth arrest. A related DNA-damage inducible gene, GADD 34 synergizes with GADD 45 or GADD 153 in suppressing cell growth. PEG-3 (progression elevated gene-3) shares significant homology with GADD 34 and is inducible by DNA damage. An additional GADD related gene, PA26, is a possible target of p53. Three isoforms of PA26 have been identified as PA26-T1, PA26-T2 and PA26-T3.

ID gène: 27244