TTBK1 anticorps (C-Term)

N° du produit ABIN501089

L’anticorps anti-TTBK1 Polyclonal Lapin est utilisé pour la détection de TTBK1 dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC (p) et EIA.

Aperçu rapide pour TTBK1 anticorps (C-Term) (ABIN501089)

Antigène: TTBK1 (tau Tubulin Kinase 1 (TTBK1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TTBK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-TTBK1 anticorps

Épitope: C-Term

Specificité: This antibody detects TTBK1. It is predicted to not cross-react with TTBK2.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography

Immunogène: TTBK1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TTBK1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TTBK1

Antigène: TTBK1 (tau Tubulin Kinase 1 (TTBK1))

Autre désignation: TTBK1

Sujet: Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.Synonyms: BDTK, Brain-derived tau kinase, KIAA1855, Tau-tubulin kinase 1

ID gène: 84630

UniProt: Q5TCY1