UCMA anticorps (C-Term)

N° du produit ABIN501098

L’anticorps Lapin Polyclonal anti-UCMA a été validé pour WB et EIA. Il convient pour détecter UCMA dans des échantillons de Humain et Souris.

Aperçu rapide pour UCMA anticorps (C-Term) (ABIN501098)

Antigène: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UCMA est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-UCMA anticorps

Épitope: C-Term

Specificité: This antibody detects UCMA.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography

Immunogène: UCMA antibody was raised against a 16 amino acid peptide near the carboxy terminus of human UCMA.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 2.5 - 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur UCMA

Antigène: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Autre désignation: UCMA

Sujet: UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.Synonyms: C10orf49, Unique cartilage matrix-associated protein

ID gène: 221044

NCBI Accession: NP_660357