ZNF350 anticorps (C-Term)

N° du produit ABIN501145

Cet anticorps Lapin Polyclonal détecte spécifiquement ZNF350 dans WB et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ZNF350 anticorps (C-Term) (ABIN501145)

Antigène: ZNF350 (Zinc Finger Protein 350 (ZNF350))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNF350 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-ZNF350 anticorps

Épitope: C-Term

Specificité: This antibody detects ZNF350.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography

Immunogène: ZBRK1 antibody was raised against a 20 amino acid peptide near the carboxy terminus of the human ZBRK1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur ZNF350

Antigène: ZNF350 (Zinc Finger Protein 350 (ZNF350))

Autre désignation: ZNF350

Sujet: ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.Synonyms: KRAB zinc finger protein ZFQR, ZBRK1, ZFQR, Zinc finger and BRCA1-interacting protein with a KRAB domain 1, Zinc finger protein 350, Zinc finger protein ZBRK1

ID gène: 59348

NCBI Accession: NP_067645