ZNF536 anticorps (N-Term)

N° du produit ABIN501163

Cet anticorps Lapin Polyclonal détecte spécifiquement ZNF536 dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ZNF536 anticorps (N-Term) (ABIN501163)

Antigène: ZNF536 (Zinc Finger Protein 536 (ZNF536))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNF536 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-ZNF536 anticorps

Épitope: N-Term

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Affinity chromatography

Immunogène: 16 amino acid peptide from near the amino terminus of human ZNF536

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot at 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur ZNF536

Antigène: ZNF536 (Zinc Finger Protein 536 (ZNF536))

Autre désignation: ZNF536

Sujet: ZNF536 is a recently identified zinc-finger protein that is expressed primarily in the developing nervous system and the cerebral cortex, hippocampus, and hypothalamus. ZNF536 possess ten zinc fingers and interacts with CtBP1, a corepressor for gene transcription. It is most closely related to transcriptional repressor ZNF219. Overexpression of ZNF536 in embryonic stem cells dramatically reduced the mRNA levels of neuronal marker genes such as Pax6, MAP2, and b-tubulin III following retinoic acid (RA)-induced differentiation, while depletion of ZNF536 via RNAi resulted in elevated mRNA levels of these genes, indicating its role in inhibiting neuronal cell differentiation. Overexpression of RA receptor a rescues the inhibitory role of ZNF536, suggesting that ZNF536 might inhibit RA response element-mediated transcriptional activity.Synonyms: KIAA0390, Zinc finger protein 532, Zinc finger protein 532

ID gène: 9745

NCBI Accession: NP_055532

Pathways: Retinoic Acid Receptor Signaling Pathway