GCET2 anticorps

N° du produit ABIN5026982

Cet anticorps anti-GCET2 est un anticorps Souris Monoclonal détectant GCET2 dans IHC. Adapté pour Humain.

Aperçu rapide pour GCET2 anticorps (ABIN5026982)

Antigène: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GCET2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: ABM43E6

Détail du produit anti-GCET2 anticorps

Purification: Protein G Chromatography

Immunogène: A full length human HGAL protein was used as the immunogen for this antibody

Isotype: IgG1 kappa

Information d'application

Indications d'application: IHC: 5 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur GCET2

Antigène: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Autre désignation: HGAL

Sujet: Human germinal center-associated lymphoma (HGAL) is specifically expressed only in germinal center (GC), B lymphocytes and GC-derived lymphomas. It is located on chromosome 3q13, comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM). HGAL decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. It also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors (Ref-1). HGAL expression by tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas.

ID gène: 257144

UniProt: Q8N6F7