BCL6 anticorps (AA 200-401)

N° du produit ABIN5027051

Cet anticorps anti-BCL6 est un anticorps Souris Monoclonal détectant BCL6 dans WB. Adapté pour Humain.

Aperçu rapide pour BCL6 anticorps (AA 200-401) (ABIN5027051)

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCL6 est non-conjugé

Application: Western Blotting (WB)

Clone: ABM44G9

Détail du produit anti-BCL6 anticorps

Épitope: AA 200-401

Purification: Protein G Chromatography

Immunogène: A partial length recombinant BCL-6 protein (amino acids 200-401) was used as the immunogen for this antibody.

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur BCL6

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Autre désignation: BCL-6

Sujet: BCL6 (B-cell lymphoma 6) is a 95 kDa zinc finger transcription factor and contains an N-terminal POZ domain. BCL6 is a transcriptional repressor and a master regulator of the germinal center (GC) B cell phenotype controlling its development and growth. BCL-6 modulates IL-4, BCR, and CD40L signals for normal B cell development. Altered BCL6 protein expression is implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL), the most common lymphoma in adults. BCL6 suppresses the expression of p53 (also known as tp53) tumor suppressor gene and modulates DNA damage-induced apoptotic responses in GC B cells.

Poids moléculaire: 72 kDa

ID gène: 604

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus