OLR1 anticorps (AA 1-200)

N° du produit ABIN5027116

L’anticorps Lapin Polyclonal anti-OLR1 a été validé pour WB. Il convient pour détecter OLR1 dans des échantillons de Humain.

Aperçu rapide pour OLR1 anticorps (AA 1-200) (ABIN5027116)

Antigène: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OLR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-OLR1 anticorps

Épitope: AA 1-200

Purification: Protein A Chromatography

Immunogène: A partial length recombinant CLEC8A protein (amino acids 1-200) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 5-6 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur OLR1

Antigène: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Autre désignation: CLEC8A/LOX-1/OLR1

Sujet: CLEC8A or OLR1 is a member of C-type lectin super family. It is the receptor that mediates the recognition and degradation of low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in inflammatory responses, pro-oxidative conditions and apoptosis. OLR1 ligation with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, Monocyte adhesion and apoptosis. OLR1 is highly expressed in vascular rich organs, like placenta, liver, lungs and brain. CLEC8A has been reported to be associated with diseases, like atherosclerosis, myocardial infarction and Alzheimer's disease. Alternative splicing produces three isoforms of CLEC8A or OLR1 whose exact function is yet to be ascertained.

Poids moléculaire: 21 kDa (Isoform)

ID gène: 4973

UniProt: P78380