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OLR1 anticorps (AA 1-200)

OLR1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5027116
  • Antigène Voir toutes OLR1 Anticorps
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Épitope
    • 16
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-200
    Reactivité
    • 60
    • 25
    • 22
    • 18
    • 2
    Humain
    Hôte
    • 39
    • 24
    • 2
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 44
    • 25
    Polyclonal
    Conjugué
    • 37
    • 6
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp OLR1 est non-conjugé
    Application
    • 46
    • 28
    • 22
    • 13
    • 13
    • 13
    • 11
    • 9
    • 8
    • 7
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Protein A Chromatography
    Immunogène
    A partial length recombinant CLEC8A protein (amino acids 1-200) was used as the immunogen for this antibody.
    Isotype
    IgG
    Top Product
    Discover our top product OLR1 Anticorps primaire
  • Indications d'application
    WB: 5-6 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS containing 0.05 % BSA, PH 7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • Antigène
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Autre désignation
    CLEC8A/LOX-1/OLR1 (OLR1 Produits)
    Synonymes
    anticorps OLR1, anticorps LOX1, anticorps Olr1, anticorps CLEC8A, anticorps LOXIN, anticorps SCARE1, anticorps SLOX1, anticorps LOX-1, anticorps SR-EI, anticorps Scare1, anticorps Oldlr1, anticorps Oldr1, anticorps PLOX-1, anticorps oxidized low density lipoprotein receptor 1, anticorps oxidized low density lipoprotein (lectin-like) receptor 1, anticorps OLR1, anticorps Olr1
    Sujet
    CLEC8A or OLR1 is a member of C-type lectin super family. It is the receptor that mediates the recognition and degradation of low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in inflammatory responses, pro-oxidative conditions and apoptosis. OLR1 ligation with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, Monocyte adhesion and apoptosis. OLR1 is highly expressed in vascular rich organs, like placenta, liver, lungs and brain. CLEC8A has been reported to be associated with diseases, like atherosclerosis, myocardial infarction and Alzheimer's disease. Alternative splicing produces three isoforms of CLEC8A or OLR1 whose exact function is yet to be ascertained.
    Poids moléculaire
    21 kDa (Isoform)
    ID gène
    4973
    UniProt
    P78380
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