Desmoglein 3 anticorps (AA 328-526)

N° du produit ABIN5027152

L’anticorps anti-Desmoglein 3 Monoclonal Souris est utilisé pour la détection de Desmoglein 3 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Desmoglein 3 anticorps (AA 328-526) (ABIN5027152)

Antigène: Desmoglein 3 (DSG3)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 3 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: ABM4A31

Détail du produit anti-Desmoglein 3 anticorps

Épitope: AA 328-526

Purification: Protein G Chromatography

Immunogène: A partial length recombinant Desmoglein 3 protein (amino acids 328-526) was used as the immunogen for this antibody.

Isotype: IgG2b kappa

Information d'application

Indications d'application: IHC: 1 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur Desmoglein 3

Antigène: Desmoglein 3 (DSG3)

Autre désignation: Desmoglein 3

Sujet: DSG3 (Desmoglein 3) is a calcium-binding transmembrane glycoprotein component of desmosomes, conferring strong cell-cell adhesion. Desmosomes are button-like points of intercellular contact that allow the attachment of cytoskeletal elements to the plasma membrane at sites of cell-cell adhesion. DSG3 is expressed in basal and immediate suprabasal layers of skin. To maintain cell-cell adhesion DSG3 interacts with other desmosomal proteins, such as plakoglobin. Plakoglobin is closely related to Beta-catenin, which is a well-known downstream effector molecule in the canonical Wnt signaling pathway.DSG3 also promotes cancer cell growth and invasion through a plakoglobin-mediated signaling pathway.

ID gène: 1830

UniProt: P32926