Importin 8 anticorps (AA 700-1000)

N° du produit ABIN5027312

Détail du produit anti-Importin 8 anticorps

Antigène: Importin 8 (IPO8)

Épitope: AA 700-1000

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Importin 8 est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant Importin-8 protein (amino acids 700-1,000) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur Importin 8

Antigène: Importin 8 (IPO8)

Autre désignation: Importin-8 (IPO8 Produits)

Synonymes: anticorps IPO8, anticorps si:ch211-116i17.1, anticorps RANBP8, anticorps 6230418K12Rik, anticorps Abcc10, anticorps C130009K11Rik, anticorps MRP7, anticorps OM-1, anticorps Om1, anticorps Ranbp8, anticorps importin 8, anticorps IPO8, anticorps ipo8, anticorps Ipo8

Sujet: Importin-8 is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. It acts as a nuclear protein involved in the nucleolar transport. Importin-8 is required for cytoplasmic miRNA-guided gene silencing and is involved in loading Ago complexes into a variety of different mRNA targets, affecting the nuclear localization of Ago proteins. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Importin-8 has been proposed previously as a reference gene in the human motor cortex as it showed no differences in a study with different brain regions from chronic alcoholics and control subjects and lung samples.

Poids moléculaire: 118 kDa

ID gène: 10526

UniProt: O15397