MUM1 anticorps (AA 52-278)

N° du produit ABIN5027376

Détail du produit anti-MUM1 anticorps

Antigène: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Épitope: AA 52-278

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUM1 est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant MUM1 protein (amino acids 52-278) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur MUM1

Antigène: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Autre désignation: MUM1 (MUM1 Produits)

Synonymes: anticorps EXPAND1, anticorps HSPC211, anticorps MUM-1, anticorps IRF4, anticorps 2610019J09, anticorps 9430059D04Rik, anticorps UBE-1C2, anticorps melanoma associated antigen (mutated) 1, anticorps PWWP domain-containing protein MUM1, anticorps MUM1, anticorps LOC612320, anticorps Mum1

Sujet: MUM1 is a member of the interferon regulatory factor family of transcription factors. This protein is required at several stages of B-cell development, including in the differentiation of mature B cell into antibody-secreting plasma cells, and is also critical for Th2 and Th17 T-cell differentiation and T-cell cytotoxic function. MUM1 is normally expressed in plasma cells, melanocytes, some B cells, and activated T cells. MUM1 acts as an architectural component of the chromatin, which in response to DNA damage serves as an accessory factor to promote cell survival. Depletion of MUM1 or inactivation of its PWWP domain resulted in chromatin compaction. Upon DNA damage, MUM1 rapidly concentrates at the vicinity of DNA damage sites via its direct interaction with 53BP1. Ablation of this interaction impaired damage-induced chromatin decondensation, which is accompanied by sustained DNA damage and hypersensitivity to genotoxic stress. MUM1 acts as a helpful marker in the differential diagnosis of AITL(Angioimmunoblastic T cell Lymphoma with HRS-like cells and cHL.

Poids moléculaire: 78 kDa

ID gène: 84939

UniProt: Q2TAK8

Pathways: Chromatin Binding