PAPPA anticorps (AA 332-561)

N° du produit ABIN5027424

Détail du produit anti-PAPPA anticorps

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Épitope: AA 332-561

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAPPA est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Protein G Chromatography

Immunogène: A partial length recombinant PAPP-A protein (amino acids 332-561) was used as the immunogen for this antibody.

Clone: ABM4C62

Isotype: IgG2b kappa

Information d'application

Indications d'application: IHC: 5-10 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur PAPPA

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Autre désignation: PAPP-A (PAPPA Produits)

Synonymes: anticorps 8430414N03Rik, anticorps IGFBP-4ase, anticorps PAG1, anticorps PAPP-A, anticorps ASBABP2, anticorps DIPLA1, anticorps PAPA, anticorps PAPPA1, anticorps Pappa, anticorps pappalysin 1, anticorps pregnancy-associated plasma protein A, anticorps PAPPA, anticorps Pappa, anticorps Pappa1

Sujet: PAPP-A (pregnancy-associated plasma protein A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. It has prognostic impact in pregnancy and acute coronary syndrome. PAPP-A regulate the activity of insulin-like growth factor (IGF) signal pathway through proteolytic degradation of IGF binding proteins (IGFBPs) thereby increasing the local concentration of free IGFs available to receptors. PAPP-A levels is associated with abnormal glucose metabolism and increased risk of atherosclerosis in AGHD (Adult Growth Hormone Deficiency) patients.

ID gène: 60676

UniProt: Q9BXP8