DNMT3A anticorps

N° du produit ABIN5027477

Détail du produit anti-DNMT3A anticorps

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DNMT3A est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: Protein G Chromatography

Immunogène: A partial length recombinant protein from DNMT3a was used as the immunogen for this antibody.

Clone: ABM13G4

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL, FACS: 0.5-1 μg/10^6

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur DNMT3A

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Autre désignation: DNMT3a (DNMT3A Produits)

Synonymes: anticorps DNMT3A, anticorps DNMT3A2, anticorps M.HsaIIIA, anticorps MmuIIIA, anticorps dnmt3a1, anticorps dnmt6, anticorps DNA methyltransferase 3 alpha, anticorps DNA methyltransferase 3A, anticorps DNA (cytosine-5-)-methyltransferase 3 alpha b, anticorps DNMT3A, anticorps Dnmt3a, anticorps dnmt3a, anticorps dnmt3ab

Sujet: Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring. Dnmt3a also directs a metabolic program by repressing key genes to enable the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been found in several cancers including AML (Acute Myeloid Leukemia).

Poids moléculaire: 15.99

ID gène: 1788

UniProt: Q9Y6K1