SPARC anticorps (AA 52-268)

N° du produit ABIN5027541

Détail du produit anti-SPARC anticorps

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Épitope: AA 52-268

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPARC est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant SPARC/Osteonectin protein (amino acids 52-268) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur SPARC

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Autre désignation: SPARC/Osteonectin (SPARC Produits)

Synonymes: anticorps ON, anticorps AA517111, anticorps BM-40, anticorps hm:zeh0062, anticorps SPARC, anticorps sparc, anticorps secreted protein acidic and cysteine rich, anticorps secreted acidic cysteine rich glycoprotein, anticorps secreted protein, acidic, cysteine-rich (osteonectin), anticorps secreted protein, acidic, cysteine-rich (osteonectin) L homeolog, anticorps secreted protein, acidic, cysteine-rich (osteonectin) S homeolog, anticorps SPARC, anticorps Sparc, anticorps sparc, anticorps sparc.L, anticorps sparc.S

Sujet: SPARC (Secreted protein, acidic, cysteine-rich) is a glycoprotein that binds to collagen type I and other proteins in the extracellular matrix. It is involved in normal tissue remodeling as it regulates the deposition of extracellular matrix, and also plays a role in neoplastic transformation. It modulates interactions between tumoral cells and the peri-tumoral stroma. Homozygous mutations in SPARC give rise to severe bone fragility in humans. SPARC negatively regulates glucose metabolism in hepatocellular carcinoma (HCC). Overexpression of SPARC inhibited glucose uptake and lactate product through downregulation of key enzymes of glucose metabolism.

Poids moléculaire: 35 kDa

ID gène: 6678

UniProt: P09486

Pathways: Autophagy