SWAP70 anticorps (AA 300-505)

N° du produit ABIN5027555

Détail du produit anti-SWAP70 anticorps

Antigène: SWAP70 (SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70))

Épitope: AA 300-505

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SWAP70 est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant SWAP70 protein (amino acids 300-505) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur SWAP70

Antigène: SWAP70 (SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70))

Autre désignation: SWAP70 (SWAP70 Produits)

Synonymes: anticorps SWAP-70, anticorps 70kDa, anticorps AV235546, anticorps HSPC321, anticorps swap70b, anticorps zgc:63599, anticorps switching B-cell complex subunit SWAP70, anticorps SWA-70 protein, anticorps SWAP switching B-cell complex 70, anticorps SWAP switching B-cell complex 70kDa subunit, anticorps switching B-cell complex subunit SWAP70a, anticorps SWAP70, anticorps Swap70, anticorps swap70, anticorps swap70a

Sujet: SWAP-70 is a 70 kDa multiple functional signaling proteins involved in formation of membrane ruffling induced by signal cascade of tyrosine kinase growth factor receptors. It is involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation in primates. Though originally isolated from activated B lymphocytes, recently it has been found that it is widely expressed in various cell types and tissues. It has a high binding afinity to PI(3,4)P2. Its intracellular localization has been reported to depend on cell activation. Stimulation of the B cell receptor triggers a translocation of SWAP-70 from the cytosol to the plasma membrane in B cells. This translocation required a functional PH-domain. SWAP-70 functions as the only B cell-specific component of an isotype switch recombination complex called SWAP. The SWAP complex has specificity for the switch regions upstream of the constant region immunoglobulin genes and it facilitates the transfer of DNA between switch regions. These features suggested that mutations in the gene encoding SWAP-70 might result in humoral immunodeficiency.

Poids moléculaire: 64 kDa

ID gène: 23075

UniProt: Q9UH65

Pathways: Production of Molecular Mediator of Immune Response