TIA1 anticorps (AA 182-385)

N° du produit ABIN5027559

Cet anticorps Souris Monoclonal détecte spécifiquement TIA1 dans WB et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour TIA1 anticorps (AA 182-385) (ABIN5027559)

Antigène: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: ABM47E1

Détail du produit anti-TIA1 anticorps

Épitope: AA 182-385

Purification: Protein G Chromatography

Immunogène: A partial length recombinant TIA-1 protein (amino acids 182-385) was used as the immunogen for this antibody.

Isotype: IgG1

Information d'application

Indications d'application: WB: 2-4 μg/mL, IHC: 5-10 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur TIA1

Antigène: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Autre désignation: TIA-1

Sujet: TIA1 (T-cell intracellular antigen) are mRNA-binding proteins that can aggregate within granules under specific stress conditions. TIA-1 is a multi-domain ribonucleic acid (RNA) binding protein that recognizes poly-uridine tract RNA sequences to facilitate 5'splice site recognition by the U1 small nuclear ribonucleoprotein (snRNP). TIA1 mutation causes perturbed RNA splicing and cellular stress resulting in WDM (Welander distal myopathy). TIA-1 regulates developmental and stress-responsive pathways through distinct activities at the levels of alternative pre-mRNA splicing and mRNA translation by recognising uridine-rich sequences of RNAs.

Poids moléculaire: 44 kDa

ID gène: 7072

UniProt: P31483