CRLF2 anticorps (AA 97-252)

N° du produit ABIN5027605

Détail du produit anti-CRLF2 anticorps

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Épitope: AA 97-252

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CRLF2 est non-conjugé

Application: Western Blotting (WB)

Purification: Protein G Chromatography

Immunogène: A partial length recombinant TSLPR protein (amino acids 97-252) was used as the immunogen for this antibody.

Clone: ABM28B6

Isotype: IgG2a kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur CRLF2

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Autre désignation: TSLP Receptor (CRLF2 Produits)

Synonymes: anticorps CRLF2, anticorps CRL2, anticorps CRLF2Y, anticorps TSLPR, anticorps CRLM2, anticorps Ly114, anticorps Tpte2, anticorps Tslpr, anticorps Crl2, anticorps cytokine receptor like factor 2, anticorps cytokine receptor-like factor 2, anticorps CRLF2, anticorps Crlf2

Sujet: TSLPR (thymic stromal lymphopoietin receptor) also known as CRLF2 (cytokine receptor-like factor 2) is a member of type I cytokine receptor. It binds its ligand TSLP (thymic stromal lymphopoietin) as a heterodimer with IL7R. TSLP ligand is produced by epithelial cells in order to activate dendritic cells, and is involved in inflammation, allergic responses as well as B-cell precursor proliferation and survival. The interaction between TSLP and its heterodimeric receptor activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. High expression of CRLF2 is associated with a poor prognosis in adult and high-risk pediatric cases of B-ALL (B-cell acute lymphoblastic leukemias).

Poids moléculaire: 42 kDa

ID gène: 64109

UniProt: Q9HC73