Cet anticorps anti-Fibrillarin/Nop1p Nucleolar Marker Monoclonal Souris (ABIN504711) détecte spécifiquement Fibrillarin/Nop1p Nucleolar Marker dans IF et WB.
L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.
Mice were injected with yeast nuclear preparations and hybridomas were screened by immunofluorescence on yeast cells and by western blotting on yeast protein homogenates.
Isotype
IgG
Indications d'application
Optimal working dilutions should be determined experimentally by the investigator.
Restrictions
For Research Use only
Format
Liquid
Stock
-20 °C
Antigène
Fibrillarin/Nop1p Nucleolar Marker
Sujet
The Nop1p protein is 327 amino acids in size (34. 5 kDa), is essential for yeast viability, and is localized in the nucleoli (1). The systematic name for S. cerevisiae Nop1 is YDL014W, and it is now known to be part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein apparently found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein.